NexGard vs Sentinel: Which Flea and Tick Treatment is Right for Your Pet?

Discover the key differences between NexGard and Sentinel for effective pet protection. Compare now!

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When it comes to protecting our furry friends from fleas and ticks, there are numerous options available in the market. Two popular choices among pet owners are NexGard and Sentinel. Both of these products are known for their effectiveness in preventing and treating flea and tick infestations.

However, they have distinct differences that make them suitable for different pets. In this article, we will compare NexGard and Sentinel to help you make an informed decision for your beloved pet’s well-being.

What is NexGard?

NexGard is a chewable flea and tick treatment that is designed for dogs. It is manufactured by the reputable pharmaceutical company, Boehringer Ingelheim. This product contains a powerful ingredient called afoxolaner, which targets and eliminates fleas and ticks effectively.

How does NexGard work?

NexGard works by interfering with the nervous system of fleas and ticks, ultimately leading to their demise. Once your dog consumes the chewable tablet, afoxolaner is rapidly absorbed into their bloodstream. When fleas or ticks bite your dog, they ingest the medication, which causes paralysis and eventually kills them.

Benefits of NexGard

  • Fast-acting: NexGard starts working within hours of administration, providing quick relief from flea and tick infestations.
  • Long-lasting protection: The effects of NexGard last for a month, ensuring continuous protection against fleas and ticks.
  • Easy administration: The chewable tablet form of NexGard makes it convenient to administer to your dog, eliminating the need for messy topical treatments.
  • Waterproof: Unlike some other flea and tick treatments, NexGard remains effective even if your dog gets wet.

What is Sentinel?

Sentinel is an oral medication that offers comprehensive protection against fleas, ticks, heartworms, and other intestinal parasites. It is produced by Novartis Animal Health and is available for both dogs and puppies.

How does Sentinel work?

Sentinel contains two active ingredients: milbemycin oxime and lufenuron. Milbemycin oxime acts by interfering with the nervous system of heartworms, fleas, and certain intestinal parasites, ultimately killing them. Lufenuron, on the other hand, inhibits the growth of flea eggs, preventing their development into adult fleas.

Benefits of Sentinel

  • Broad-spectrum protection: Sentinel not only protects against fleas and ticks but also prevents heartworm disease and controls other intestinal parasites such as roundworms and hookworms.
  • Convenient monthly dosing: With just one tablet per month, you can ensure your dog is protected from multiple parasites.
  • Safe for most dogs: Sentinel is safe to use in most dogs, including puppies as young as four weeks old.
  • Effective flea control: By preventing the development of flea eggs, Sentinel helps break the flea life cycle and reduces infestations in your home.

NexGard vs Sentinel: A Comparison

Now that we have a basic understanding of NexGard and Sentinel, let’s compare them side by side to determine which one may be more suitable for your pet.


Both NexGard and Sentinel are highly effective in their respective areas of protection. NexGard is particularly known for its fast-acting formula, providing quick relief from fleas and ticks. On the other hand, Sentinel offers comprehensive protection against a wider range of parasites, including heartworms and intestinal worms.


NexGard is a chewable tablet that dogs generally find palatable, making it easy to administer. Sentinel is also an oral tablet, but it does not have the same appealing flavor as NexGard. Some dogs may require the tablet to be hidden in food or treats for easier administration.


Both NexGard and Sentinel have been extensively tested for safety and are generally well-tolerated by dogs. However, it is important to note that individual sensitivities and allergies can occur. It is recommended to consult with your veterinarian before starting any new medication for your pet.

Waterproof Protection

NexGard is waterproof, which means it remains effective even if your dog goes swimming or gets wet. Sentinel, on the other hand, is not waterproof. If your dog is frequently exposed to water, NexGard may be a more suitable option.


The cost of NexGard and Sentinel can vary depending on factors such as the size of your dog and the number of tablets required. It is advisable to compare prices from different sources and consult with your veterinarian to determine the most cost-effective option for your pet’s needs.


In conclusion, both NexGard and Sentinel are effective flea and tick treatments that offer unique benefits. NexGard is known for its fast-acting formula and waterproof protection, making it ideal for dogs that are frequently exposed to water. Sentinel, on the other hand, provides comprehensive protection against fleas, ticks, heartworms, and intestinal parasites, making it a convenient all-in-one solution.

Ultimately, the choice between NexGard and Sentinel will depend on your pet’s specific needs and your veterinarian’s recommendation. Remember to prioritize your pet’s well-being and consult with a professional to ensure you select the most suitable treatment option.

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