NexGard vs Trifexis: A Comprehensive Comparison

Discover the key differences between NexGard and Trifexis for effective flea and tick control.

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When it comes to protecting our furry friends from fleas, ticks, and other parasites, it’s important to choose the right product. Two popular options on the market are NexGard and Trifexis. In this article, we will delve into the key differences and similarities between these two medications, helping you make an informed decision for your beloved pet’s health.

What is NexGard?

NexGard is a monthly chewable tablet that provides protection against fleas and ticks for dogs. It contains the active ingredient afoxolaner, which kills fleas before they have a chance to lay eggs and eliminates ticks, including the American dog tick, black-legged tick, and Lone Star tick. NexGard is a prescription medication and should only be used under veterinary supervision.

What is Trifexis?

Trifexis, on the other hand, is a combination medication that offers protection against fleas, heartworms, roundworms, hookworms, and whipworms. It contains two active ingredients: spinosad, which kills fleas, and milbemycin oxime, which prevents heartworm disease and treats intestinal parasites. Trifexis is also a prescription medication and should be administered under the guidance of a veterinarian.


Both NexGard and Trifexis have been proven effective in preventing and treating flea infestations. However, it’s important to note that NexGard specifically targets fleas and ticks, while Trifexis provides a broader spectrum of protection against fleas, heartworms, and various intestinal parasites. If your furry friend is at risk of multiple parasitic infections, Trifexis may be the better option.


When it comes to the safety of our pets, it’s crucial to consider any potential side effects associated with these medications. According to clinical studies, the most common adverse reactions reported for NexGard include vomiting, dry skin, diarrhea, and lethargy. On the other hand, Trifexis has been associated with side effects such as vomiting, decreased appetite, and diarrhea. It’s important to consult with your veterinarian to determine which option is safest for your pet.


NexGard and Trifexis are both administered orally, making them convenient options for pet owners. NexGard comes in a chewable tablet form with a beef-flavored taste that dogs find palatable. Trifexis, on the other hand, is also a chewable tablet but does not have a specific flavor. If your pet has a picky palate, NexGard may be the preferred choice.

Heartworm Prevention

Heartworm disease is a serious and potentially fatal condition that can affect dogs. Both NexGard and Trifexis offer protection against heartworms, but Trifexis also treats and controls other intestinal parasites. If your dog is at risk of heartworm disease and you want comprehensive protection against other common parasites, Trifexis may be the better option for you.

Price Comparison

Price is often a deciding factor when it comes to choosing between NexGard and Trifexis. While the cost can vary depending on the size of your dog and the quantity of tablets required, Trifexis is generally more expensive than NexGard. However, considering the additional protection it provides against heartworms and intestinal parasites, the higher price may be justified for some pet owners.


In the battle of NexGard vs Trifexis, there is no clear winner. The best choice for your furry friend depends on their specific needs and your preferences as a pet owner. If your dog is at risk of multiple parasitic infections and you want comprehensive protection, Trifexis may be the better option. However, if you are primarily concerned about fleas and ticks and prefer a flavored chewable tablet, NexGard may be the right choice. Consult with your veterinarian to determine the most suitable medication for your pet’s health.

nexgard vs trifexis

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